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Seredyn (BioNeurix)

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    The serenity of SEREDYN is achieved by combining the wisdom of nature with the power of science. Clinical research suggests that the natural compounds in SEREDYN can help relieve anxiety, insomnia, and panic attacks. By supporting the brain�s natural ability to relax, SEREDYN restores tranquility to your life without expensive or habit-forming drugs.

    SEREDYN'S proprietary formula quiets the restless mind and soothes the wounded spirit. Up to 90% of users report that SEREDYN effectively relieves feelings of anxiety. We encourage you to review the scientific research discussing the benefits of the SEREDYN formula. You can also learn more about how SEREDYN works to restore emotional harmony.

    Because SEREDYN is a natural supplement, it can be purchased without a prescription.


    The natural ingredients in SEREDYN affect the "circuits" in the brain responsible for mood, emotion and relaxation. By interacting with your brain�s emotional pathways, SEREDYN reduces anxiety and supports a calm and confident outlook.

    The amino acid in SEREDYN, l-theanine, increases the activity of a neurotransmitter called GABA. (A neurotransmitter is a natural compound used by the brain to send messages from one nerve cell to another.) Anxiety and panic attacks often result from low levels of GABA. By naturally increasing the activity of GABA in the brain, l-theanine promotes a sense of tranquility and relieves anxiety. Furthermore, l-theanine increases the activity of another neurotransmitter, dopamine, which promotes concentration and confidence. Thus, l-theanine calms without causing drowsiness or sedation. Interestingly, the relaxing and focusing effects of green tea result from its high l-theanine content.

    Another ingredient in SEREDYN, Valerian extract, has been used as an anti-anxiety remedy for centuries and has been clinically shown to relieve anxiety-related insomnia. Valerian reduces anxiety by interacting with a neurotransmitter called adenosine, a natural chemical messenger used by the brain to regulate arousal and reduce overstimulation. Recent research suggests that certain constituents of Valerian extract bind to and activate adenosine receptors in the brain. Adenosine provides a calming effect and helps regulate sleep patterns, and by increasing adenosine activity Valerian produces these same relaxing feelings. (Note that caffeine works by blocking adenosine receptors, which is why too much coffee may produce anxiety and "the jitters".) Research also suggests that Valerian may increase the activity of GABA, a neurotransmitter that relieves anxiety and promotes a cool, confident attitude. SEREDYN contains high-quality Valerian extract standardized to 0.8% valerinic acid, the clinically proven potency.

    Clinical research suggests that the third ingredient in SEREDYN, Passion Flower extract, relieves anxiety as effectively as some prescription anti-anxiety medications. A combination of Passion Flower and Valerian, as found in SEREDYN, may be particularly effective. Studies also demonstrate that Passion Flower reduces the negative, anxiety-related symptoms of withdrawal from alcohol, opiates, and benzodiazepine anti-anxiety drugs. This makes Passion Flower ideal for individuals trying to reduce their dependence on alcohol or prescription anti-anxiety medications. Although the exact mechanism of Passion Flower is unknown, its primary effect is to quiet the restless mind. The Passion Flower extract found in SEREDYN is standardized to contain 4% vitexin.

    SEREDYN is manufactured according to rigorous quality-control guidelines to ensure consistent potency and purity. When taken as directed, the ingredients in SEREDYN are safe and side effects are rare. Unlike many prescription anti-anxiety drugs, SEREDYN is not addictive or habit-forming. You won't develop a tolerance to SEREDYN or experience uncomfortable withdrawal symptoms if you decide to stop taking it. And because it�s a natural supplement, SEREDYN can be obtained without a prescription.


    Passion Flower As Effective as Oxazepam for General Anxiety Disorder

    A double-blind randomized trial published in the Journal of Clinical Pharmacy and Therapeutics found Passiflora extract to relieve anxiety as effectively as oxazepam, a prescription anti-anxiety drug similar to diazepam (Valium�) and alprazolam (Xanax�). According to the researchers, "The results suggest that Passiflora extract is an effective drug for the management of generalized anxiety disorder, and the low incidence of impairment of job performance with Passiflora extract compared to oxazepam is an advantage."1 SEREDYN contains the recommended dose of Passiflora extract.

    Passion Flower Relieves Anxiety-Related Symptoms of Alcohol, Benzodiazepine, and Opiate Withdrawal

    Individuals withdrawing from anxiety-reducing drugs such as benzodiazepines (e.g. Valium�, Xanax�, Ativan�), opiates, and alcohol often experience intense anxiety, irritability, nervousness, and restlessness, and general mental discomfort. Various randomized, controlled studies indicate that Passiflora extract, similar to the extract found in SEREDYN, helps to relieve the anxiety-related symptoms of sedative and opiate withdrawal.2,3,4

    [Note that abrupt withdrawal from alcohol and benzodiazepines can be life-threatening. If you are currently taking alcohol, benzodiazepines, or opiates on a daily basis, consult a physician before stopping. The research above indicates that the ingredients in SEREDYN can be helpful for anxiety-related emotions induced by discontinuation of sedative drugs, but SEREDYN should not be considered a replacement for any prescription medication or a treatment for alcohol, benzodiazepine, or opiate dependence.]

    Combination of Valerian and Passion Flower Reduces Anxiety Symptoms

    An article published in the Quarterly Review of Natural Medicine reported that Valerian and Passion Flower, when used in combination, reduce symptoms in people suffering from anxiety.5 SEREDYN combines effective doses of Valerian and Passion Flower extract.

    Review of L-Theanine Research

    A growing body of research demonstrates the ability of L-theanine to calm both mind and body. The dose of L-theanine found in SEREDYN directly stimulates the production of alpha brain waves6, creating a state of mental relaxation and concentration similar to that obtained by meditation. And L-theanine stimulates the release of GABA7, a neurotransmitter that reduces anxiety and provides a sense of calm and well-being. L-theanine may relieve mental distress associated with PMS and menopause8. Research using hypertensive rats demonstrates that L-theanine can lower blood pressure9, although similar research has not yet been performed in humans. The ability of L-theanine to relieve anxiety is only now being fully appreciated.

    Please keep in mind that SEREDYN has not been approved by the Food and Drug Administration for the treatment of anxiety disorder, panic disorder, or any other medical condition. The statements found above have not been evaluated by the Food and Drug Administration. SEREDYN is an herbal dietary supplement, not a drug. SEREDYN should not be considered a substitute for FDA-approved medications or professional medical treatment.

    (1) Akhondzadeh S, Naghavi HR, Vazirian M, Shayeganpour A, Rashidi H, Khani M. Passionflower in the treatment of generalized anxiety: a pilot double-blind randomized controlled trial with oxazepam. J Clin Pharm Ther. 2001 Oct;26(5):363-7.
    (2) Akhondzadeh S, Kashani L, Mobaseri M, Hosseini SH, Nikzad S, Khani M. Passionflower in the treatment of opiates withdrawal: a double-blind randomized controlled trial. J Clin Pharm Ther. 2001 Oct;26(5):369-73.
    (3) Dhawan K, Dhawan S, Chhabra S. Attenuation of benzodiazepine dependence in mice by a tri-substituted benzoflavone moiety of Passiflora incarnata Linneaus: a non-habit forming anxiolytic. J Pharm Pharm Sci. 2003 May-Aug;6(2):215-22.
    (4) Dhawan K, Kumar S, Sharma A. Suppression of alcohol-cessation-oriented hyper-anxiety by the benzoflavone moiety of Passiflora incarnata Linneaus in mice. J Ethnopharmacol. 2002 Jul;81(2):239-44.
    (5) Brown D. Valerian root: Non-addictive alternative for insomnia and anxiety. Quart Rev Nat Med 1994 Fall; 221-4 [review].
    (6) Kobayashi K, Nagato Y, Aoi N, Juneja LR, Kim M, et al. Effects of L-theanine on the release of a-brain waves in human volunteers. Nippon Nogeikagaku Kaishi. 1998;72:153-7.
    (7) Kimura R, Murata T. Influence of alkylamides of glutamic acid and related compounds on the central nervous system. I. Central depressant effect of theanine. Chem Pharm Bull (Tokyo). 1971;19(6):1257-61.
    (8)Ueda T, Nagato Y, Tanaka Y, Okubo T, Kobayashi K, et al. Composition comprising theanine. US Patent 6,589,566; July 8, 2003.
    (9) Yokogoshi H, Kato Y, Sagesaka YM, Takihara-Matsuura T, Kakuda T, et al. Reduction effect of theanine on blood pressure and brain 5-hydroxyindoles in spontaneously hypertensive rats. Biosci Biotechnol Biochem. 1995;59(4):615-8.


    SEREDYN is safe and usually well tolerated. Most people who take SEREDYN do not experience side effects. When side effects do occur, they tend to be mild and often disappear.

    You can safely take SEREDYN with all nutritional supplements and most prescription medications. Please review the list of drug interactions before taking SEREDYN.

    When taken as directed, SEREDYN is safe and poses no short-term or long-term health risks. Read the contraindications and precautions before taking SEREDYN.


    SEREDYN has been scientifically formulated to quiet the anxious mind using the latest advances in the fields of psychology, nutrition and neuroscience.

    Our laboratory follows rigorous quality-assurance procedures when manufacturing SEREDYN. SEREDYN contains only standardized plant extracts and pharmaceutical-grade amino acids to ensure maximum purity and potency.

    The recommended dose of SEREDYN is one or two capsules up to three times daily. The proprietary SEREDYN formula contains:

    L-Theanine (SunTheanine�) (99% pure L-theanine):
    L-theanine, an amino acid found in green tea, produces a pronounced feeling of tranquility in as little as fifteen (15) minutes. L-theanine increases the activity of GABA, a neurotransmitter (i.e. natural messenger in the brain) that promotes relaxation and reduces anxiety. L-theanine also stimulates the release of dopamine, a neurotransmitter responsible for confidence and a sense of well-being. Learn more...

    Passion Flower (Passiflora incarnata) extract standardized to 4% vitexin.
    Healers have used Passion Flower as a natural remedy for anxiety and insomnia for centuries. Recent research verifies that standardized Passion Flower extract reduces anxiety and promotes a positive outlook. Passion Flower may also reduce anxiety-related discomfort caused by opiate and sedative withdrawal. Learn more...

    Valerian (Valeriana officinalis) extract standardized to 0.8% valerenic acid
    Standardized Valerian extract, a safe and effective natural sedative, calms both mind and body. Clinical research demonstrates that Valerian effectively relieves anxiety-related insomnia and suggests that Valerian extract may be comparable to some prescription anti-anxiety drugs for treating anxiety disorders. Unlike many drugs, however, Valerian is not addictive or habit-forming when taken in recommended doses. Learn more...

    Niacinamide is a form of niacin that has anxiolytic (anti-anxiety) properties. Unlike regular niacin, however, niacinamide does not cause flushing or stress the liver.

    Magnesium Taurinate
    Provides the mineral magnesium and the amino acid taurine, both of which calm the mind and support mental wellbeing.


    Please note that it's normal for SEREDYN capsules to have a pungent odor. This is due to the Valerian extract in SEREDYN and does not indicate that the capsules are spoiled or defective.

    Manufactured by:

    BioNeurix, Inc.

    Revised - July 2008

    © 20085 BioNeurix Corporation

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    This page was last modified 30-JUN-07
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